Chemistry Journal of Moldova

SUBSTITUTED 1,3-PHENYL(PYRIDYL) PROPENONES AND DERIVATIVES WITH THIOSEMICARBAZIDIC GROUPS. STRUCTRURE – (HL-60) ANTILEUKEMIA ACTIVITY RELATIONSHIP

Author(s):

Ana Popusoi, Nicanor Barba, Aurelian Gulea, Jenny Roy, Donald Poirier


Field: Organic chemistry
Type: Research paper
Issue: 2014 Volume 9, no.2
Pages: 67-73
Keywords:

chalcones, isothiocyanatopropenones, thioureas, antileukemia activity


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Abstract (PDF)

DOI:
dx.doi.org/10.19261/cjm.2014.09(2).10

Graphical Abstract: 
3-(4-(Dimethylamino)phenyl-1-(4-isothiocyanatophenyl)prop-2-en-1-one was obtained from the corresponding N,N-dimethylthyoureas by elimination of dimethylamine at heating with gaseous hydrogen chloride in chloroform and 1-(4-isothiocyanatophenyl)-3-(pyridin-2-il)prop-2-en-1-one by treating 1,1-dimethyl-3-(4-(3-(pyridin-2-il)-acryloyl)-phenyl)thyourea with acetic anhydride. For all obtained compounds in the course of reaction the antileukemia activity was investigated.



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