Chemistry Journal of Moldova

THE SYNTHESIS OF NEW SPIROLACTONES FROM SUBSTITUTED ISATINS

Author(s):

Natalia Sucman, Vsevolod Pogrebnoi, Mykola Obushak, Elena Melnic, Victor Kravtsov, Fliur Macaev


Field: Organic chemistry
Type: Research paper
Issue: 2015 Volume 10, no.1
Pages: 64-70
Keywords:

spirolactones, isatins, triphenylphosphine, dimethyl acetylenedicarboxylate.


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Abstract (PDF)

DOI:
dx.doi.org/10.19261/cjm.2015.10(1).09

Graphical Abstract:
 Described synthesis of 5-bromo substituted oxindoles linkages in spirocyclic butenolides exhibit relatively dependence of the structure-reactivity relationships of N-substituted isatines, dimethyl acetylenedicarboxylate and triphenylphoshine. The study of the stereochemistry of the atom C(2) of the spiro compounds was also unambiguously confirmed by single crystal X-ray analysis. 

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