Chemistry Journal of Moldova

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DOI: dx.doi.org/10.19261/cjm.2009.04(2).17

Graphical Abstract: (-)-Drimenol is a relatively accessible compound, that has been and may be further used as a starting material to prepare sesquiterpenoids. The present review deals with the methods of obtaining of this compound as well as its usage.


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DOI: dx.doi.org/10.19261/cjm.2008.03(2).01

Graphical Abstract: A relatively simple method for isolation of the mixture of ent-kaur-16-en-19-oic (1) and ent-trachiloban-19-oic (2) acids from dry waste of sunflower processing has been elaborated, and it has been shown that the waste can serve as an accessible source of ent-kauranic and ent-trachilobanic diterpenoids.


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DOI: dx.doi.org/10.19261/cjm.2008.03(2).05

Graphical Abstract: New ionic liquids bearing an imidazolium core with a carboxy group have been prepared in an attempt to design new organocatalysts of Biginelli reaction. Trends in the properties of these compounds are discussed. The synthetized compounds represented a novel class of molted salts and may be considered as new organocatalysts for chemical reaction.


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DOI: dx.doi.org/10.19261/cjm.2008.03(2).07

Graphical Abstract: A new flavonol glycoside, 5,4′-dimethylkaempferol 3-O-β-D-(6′′-α-Lrhamnopyranosyl) -glucopyranoside, together with three known compounds were isolated from the n-butanolic soluble fraction of underground and aerial parts of Linaria vulgaris Mill, collected on the territory of Moldova. The characterisation of these compounds was achieved by various chromatographic and spectroscopic methods (IR, UV, 13C-NMR, 1H-NMR and MS).


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DOI: dx.doi.org/10.19261/cjm.2008.03(2).08

Graphical Abstract: Three phenylethanoid glycosides (1, 2, 3) and one iridoid glycoside (4) were isolated from aerial parts of Veronica chamaedrys L. (Scrophulariaceae) for the first time. On the basis of spectral analysis, the structures of these compounds were determined to be acteoside (3,4-dihydroxy-β-phenylethoxy-O-α-L-rhamnopyranosyl-(1→3)-4-O-caffeoyl-β-D-glucopyranoside) (1), ehrenoside (3,4-dihydroxy-β-phenylethoxy-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranosyl-(1→3)-4-O-caffeoyl-β-D-glucopyranoside) (2), chamaedroside (3,4-dihydroxy-β-phenylethoxy-O-α-L-rhamnopyranosyl-(1→3)-4-O-caffeoyl-α-L-arabinopyranoside) (3) and aucuboside (4).


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DOI: dx.doi.org/10.19261/cjm.2008.03(2).10

Graphical Abstract: The method for synthetising new derivatives of the pinonic acid using, at the key step, the reaction of condensation with epichlorohydrin, has been elaborated. It has been shown that, in the presence of catalytic amount of tetrabutylammonium chloride, the reaction is directed towards the formation of etherchlorohydrin, which, later on, is easily transformed into epoxides as well as chloromethyldiketones with good overall yield.


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DOI: dx.doi.org/10.19261/cjm.2008.03(2).19

Graphical Abstract: This review deals the methods of preparation of the 11-bishomodrimane-8α-ol-12-one, a convenient synton for the synthesis of drimanic and bishomodrimanic compounds, including the biologically active ones. The triterpenic tetracyclic derivatives of the onoceranic range and the fragrance compounds with ambergris odour can be also obtained from this compound.


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DOI: dx.doi.org/10.19261/cjm.2008.03(1).10

Graphical Abstract: Ten steroidal saponins have been isolated form the seeds of Hyoscyamus niger L. for the first time and their structures have been elucidated. Seven saponins belong to spirostane series, two are furostane-type and one is pregnane glycoside. Hyoscyamosides B, C and C2 are new steroidal saponins, which have never been reported before in literature. Complete assignments of the 1H and 13C NMR chemical shifts for all these glycosides were achieved by means of one- and two-dimensional NMR techniques, including 1H–1H COSY, HSQC, HMBC and ROESY spectra.

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DOI: dx.doi.org/10.19261/cjm.2007.02(1).04

Graphical Abstract: A mixture of 7α- and 17-bromonorambreinolides was obtained on treatment of the mixture of isomeric methyl bicyclohomofarnesenoates, the norambreinolide transesterification product, with NBS and H2O2. The structure of 7α- and 17-bromonorambreinolides was elucidated on the basis of spectral data. The structure of 17-bromonorambreinolide was confirmed by its reduction with LiAlH4 into sclaradiol, and that of 7α-bromonorambreinolide by X-ray analysis.


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