Chemistry Journal of Moldova

Natural product chemistry and synthesis

Author(s):

V. Kulcitki


Field: Natural product chemistry and synthesis
Type: Review
Issue: 2012 Volume 7, no.2
Pages: 46-56
Keywords: terpenoids, biomimetic synthesis, cyclisation, rearrangement, oligomerisation, functionalisation.
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DOI:
dx.doi.org/10.19261/cjm.2012.07(2).14

Graphical Abstract:
 The current paper represents an outline of the selected contributions to the biomimetic procedures and approaches for the synthesis of terpenes with complex structure and diverse functionalisation pattern. These include homologation strategies, cyclisations, rearrangements, as well as biomimetic remote functionalisations.


Downloads: 38

Author(s):

Alexandra Marchenko, Pavel Kintia, Bożena Wyrzykiewicz


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2010 Volume 5, no.2
Pages: 54-58
Keywords: steroidal glycoside, NMR analysis, Veronica chamaedrys L.
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DOI:
dx.doi.org/10.19261/cjm.2010.05(2).07

Graphical Abstract:
The paper reports on the structural elucidation of the four steroidal glycosides, where two are new, isolated from Veronica chamaedrys L. plants for the first time on the basis of extensive spectral analysis, including 2D NMR spectral data and chemical evidences.


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Author(s):

N. Secara, Gh. Duca, L. Vlad, F. Macaev


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2010 Volume 5, no.2
Pages: 59-67
Keywords: dihydroxyfumaric acid derivatives, DPPH test, antioxidant activity.
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DOI:
dx.doi.org/10.19261/cjm.2010.05(2).08

Graphical Abstract:
The paper describes the syntheses of new derivatives of dihydroxyfumaric acid and investigations of their antioxidant activities using the DPPH method.


Downloads: 35

Author(s):

Marina Grinco, Olga Chetraru, Veaceslav Kulciţki, Alic Barba, Alexandr Boico, Pavel F. Vlad and Nicon Ungur


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2010 Volume 5, no.1
Pages: 106-108
Keywords: diterpene, isolation, synthesis, 15α-angeloyl-ent-kaur-16-en-19-oic acid, 15α-hydroxy-ent-kaur-19-oic acid, 15-oxo-ent-kaur-16-en-19-oic acid.
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Downloads: 44

Author(s):

Veaceslav Kulciţki, Marina Cara, Andrea Bourdelais, Tomas Schuster and Daniel Baden


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2010 Volume 5, no.1
Pages: 118-120
Keywords: Terpenoids, furans, NBS, conjugate addition.
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DOI:
dx.doi.org/10.19261/cjm.2010.05(1).13

Graphical Abstract:
 Conjugate 1,4-addition of N-bromosuccinimide (NBS) to a diene system, possessing a suitable oxygen functionality, leads to functionalized  tetrahydrofuran derivatives, which can be further derivatized into different synthetic targets.



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Author(s):

Olga Chetraru, Marina Grinco, Veaceslav Kulciţki, Pavel F. Vlad and Nicon Ungur


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2010 Volume 5, no.1
Pages: 121-123
Keywords: Terpenoids, biomimetic synthesis, kaurane, atisane, beyerane.
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DOI:
dx.doi.org/10.19261/cjm.2010.05(1).14

Graphical Abstract: 
The direct, one step conversion of ent-kaurenoic acid 3 into atisanic and beyeranic acids 1 and 2 was performed under the action of fluorosulfonic acid.


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Author(s):

M. Gavagnin, V. Kulcitki


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.2
Pages: 7-8
Keywords:
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DOI:
dx.doi.org/10.19261/cjm.2011.06(2).01

Moldovan chemists hosted the Italian partners in Chisinau and organized in premiere for the last 20 years an international seminar devoted to the chemistry of natural products. The seminar’s motto: New Frontiers in the Chemistry of Natural Products has addressed numerous students and researchers acting in the fields of chemistry, biology, pharmacy, genetics, biophysics as well as specialists from the R&D sector of companies with chemico-pharmaceutical profile. Following multiple solicitations coming from seminar audience, made us provide in the current issue of the  “Chemistry Journal of Moldova. General, Industrial and Ecological Chemistry” a condensed abstract of the seminar presentations. We do really hope that our joint event will give further impetus to our collaboration and will also motivate other researchers from Moldova to develop partnerships with European colleagues.


Downloads: 16

Author(s):

M. L. Ciavatta


Field: Natural product chemistry and synthesis
Type: Invited paper
Issue: 2011 Volume 6, no.2
Pages: 9-12
Keywords: NMR techniques, natural products, marine compounds.
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DOI:
dx.doi.org/10.19261/cjm.2011.06(2).02

Graphical Abstract:
 The topic of the seminar held in the Institute of Chemistry, Academy of Sciences of Moldova on 30th September in the frame of the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, concerned the use of NMR techniques in the elucidation of natural products. Step by step, two marine compounds (Fulvyne C and Tritoniopsin A) belonging to different chemical classes have been analyzed, by using suitable NMR experiments. This powerful technique allowed the elucidation of compounds as fulvynes, long chain polyacetylenes with the same functional groups but differently located in the chain, as well as tritoniopsins, cyclic diterpenes with a new skeleton, providing further information on their relative and absolute stereochemistry.



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Author(s):

A. Ciocarlan, P. F. Vlad, M. Coltsa, C. Edu, A. Biriiac, A. Nicolescu and C. Deleanu


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.2
Pages: 13-15
Keywords: natural product chemistry, larixol, sclareol.
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DOI:
dx.doi.org/10.19261/cjm.2011.06(2).03

Graphical Abstract:
 The current communication represents an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 30 September. An overview of the synthetic methods oriented to the synthesis of C6 and C7 functionalized euryfurans is provided.



Downloads: 34

Author(s):

T. Cotelea


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.2
Pages: 16-18
Keywords: Cannabis compounds, metabolism, pharmacological action, phisico-chemical analysis.
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DOI:
dx.doi.org/10.19261/cjm.2011.06(2).04

Graphical Abstract:
 The current communication includes a general overview of the scientific interest and medicianl chemistry aspects of Cannabis compounds. It relates to metabolism, pharmacological action and phisico-chemical analysis of these compounds, as well as of some isomers differing in spatial arrangement of functional groups.


Downloads: 25