IMPLICATIONS OF GLOBAL AND LOCAL MOBILITY IN AMORPHOUS EXCIPIENTS AS DETERMINED BY DSC AND TM DSC
Author(s): Ion Dranca, Tudor Lupascu
Field: Physical chemistry and chemical physics
Type: Research paper
Issue: 2009 Volume 4, no.2
Pages: 105-115
Keywords: molecular mobility; excipients (sucrose & trehalose); α- and β-relaxations; activation energy; DSC & TM DSC.
Full Text (PDF): Download
DOI: dx.doi.org/10.19261/cjm.2009.04(2).02
Graphical Abstract: The paper explores the use of differential scanning calorimetry (DSC) and temperature modulated differential scanning calorimetry (TM DSC) to study α- and β- processes in amorphous sucrose and trehalose. The real part of the complex heat capacity is evaluated at the frequencies,
f, from 5 to 20mHz. β-relaxations were studied by annealing glassy samples at different temperatures and subsequently heating at different rates in a differential scanning calorimeter.
Downloads: 10