Chemistry Journal of Moldova

IMPLICATIONS OF GLOBAL AND LOCAL MOBILITY IN AMORPHOUS EXCIPIENTS AS DETERMINED BY DSC AND TM DSC

Author(s):

Ion Dranca, Tudor Lupascu


Field: Physical chemistry and chemical physics
Type: Research paper
Issue: 2009 Volume 4, no.2
Pages: 105-115
Keywords:

molecular mobility; excipients (sucrose & trehalose); α- and β-relaxations; activation energy; DSC & TM DSC.


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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2009.04(2).02

Graphical Abstract:
 The paper explores the use of differential scanning calorimetry (DSC) and temperature modulated differential scanning calorimetry (TM DSC) to study α- and β- processes in amorphous sucrose and trehalose. The real part of the complex heat capacity is evaluated at the frequencies, f, from 5 to 20mHz. β-relaxations were studied by annealing glassy samples at different temperatures and subsequently heating at different rates in a differential scanning calorimeter.

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